منابع مشابه
Textbook germinal centers?
Models for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny. Indeed, recent studies have called several of their principal assumptions into question. In addition, the term germ...
متن کاملGerminal Centers without T Cells
Germinal centers are critical for affinity maturation of antibody (Ab) responses. This process allows the production of high-efficiency neutralizing Ab that protects against virus infection and bacterial exotoxins. In germinal centers, responding B cells selectively mutate the genes that encode their receptors for antigen. This process can change Ab affinity and specificity. The mutated cells t...
متن کاملThymoma and thymic germinal center.
A previous study of 70 cases of thymoma described in 1966 by the author1 reported that definite germinal centers were found in the normal thymic tissue attached to one case of thymoma associated with myasthenia gravis, and that this was very interesting from the point of view of whether thymoma or thymic germinal center was a more important occurrence of a myasthenic condition. Since then routi...
متن کاملSnapShot: The Germinal Center Reaction
To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted mutagenesis and affinity-based selection. These cycles take place in a structure known as the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic stimuli. Here, we summarize our current understanding of the germinal center reaction.
متن کاملIntroduction to the Proceedings of the 12Th Germinal Centre Conference — Thirty Years of Germinal Centre Conferences
"In Vivo Veritas": Under this motto, the twelfth socalled Germinal Centre Conference was held in Graz, Austria, July 1 to 5, 1996, with Prof. Konrad Schauenstein chairing the organizing committee, with the assistance of Dr. Richard Boyd (Australia). Despite the progress that is being made using in vitro models, some immunologists believe that "the proof of the pudding is in the eating", that is...
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ژورنال
عنوان ژورنال: Revista Intertexto
سال: 2011
ISSN: 1981-0601,1981-0601
DOI: 10.18554/ri.v3i2.109